Serotonin & the Pancreas

Platelet aggregation, platelet serotonin and pancreatitis.

Positron emission tomography ligand [11C]5-hydroxy-tryptophan can be used as a surrogate marker for the human endocrine pancreas.

In humans, a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of β-cells, with healthy...

Serotonin's Role in the Pancreas Revealed at Last

Serotonin is best known as a neurotransmitter in the brain. Released by one neuron and picked up by another, it regulates mood and aggression. Many antidepressants, and the party drug Ecstasy, increase serotonin stimulation. But it is found outside the central nervous system as well, including in the pancreas, specifically in the beta cells that release insulin to regulate blood glucose levels....

Some physiological observations on the exocrine pancreas. The effects of some agents on pancreatic secretion.

Many problems are left unsolved on the exocrine pancreas. Pancreatic secretion is controlled by various factors while maintaining close relations with neighbouring organs. From the view point that the stomach and the pancreas are closely associated by way of gastrointestinal hormones, the factors involved in the mechanism of pancreatic secretion were investigated experimentally and clinically b...

Tryptophan rich diet as a new approach to study the serotoninergic enteropancreatic axis.

The influence of a tryptophan enriched diet (L-tryptophan added as 1% of total diet), fed over 10 days, on the rat duodenum and pancreas was studied by immunohistology, measurements of serotonin and tryptophan tissue concentrations by HPLC, and incubations of pancreatic lobules. Ingestion of a tryptophan enriched diet resulted in increased contents of tryptophan and serotonin in the duodenum th...